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Nicotinamide phosphorybosiltransferase overexpression in thyroid malignancies and its correlation with tumor stage and with survivin/survivin DEx3 expression

K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas

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It uses glutathione to bind to toxins, heavy metals, and metabolic waste, making them water-soluble so they can be excreted

Intracellular succinate can also be exported to the extracellular space and enter the circulatory system, such as in skeletal muscle cells, where succinate can be secreted into the extracellular milieu by MCT1 and bind to the succinate receptor-1 (SUCNR-1) on non-myofibrillar resident cells, activating downstream signaling pathways like ERK1/2 and PI3K-AKT [75, 76]